contentSlug

type

ContentSlug_ContentQuery

slug

ContentPageContentQuery

content

trendingContent

query ContentSlug_ContentQuery(
  $contentSlug: String!
  $type: [ContentType!]
) {
  ...ContentPageContentQuery_13QmVO
}

fragment CompanyDetails_Content on Content {
  __isContent: __typename
  companies {
    name
    description
    pageUrl
    id
  }
}

fragment CompanyTagList on Company {
  pageUrl
  name
  viewerIsFollowing
}

fragment ContentBasicInfo on Content {
  __isContent: __typename
  id
  type
  title
  lang
  companies {
    ...CompanyTagList
    id
  }
  ...PublishingDetails
  ...Reactions
}

fragment ContentMetadata on Content {
  __isContent: __typename
  type
  title
  lang
  pageUrl
  alternatePageUrls {
    pageUrl
    lang
  }
  imgUrl
  description
  ... on Video {
    liveTime
    videoUrl
  }
  ... on Webcast {
    liveTime
    videoUrl
  }
}

fragment ContentPageContentQuery_13QmVO on Query {
  content(slug: $contentSlug, type: $type) {
    __typename
    id
    type
    title
    isPremium
    lang
    htmlBody
    companies {
      forum {
        latestPosts {
          ...ForumPosts
        }
      }
      defaultInstrument {
        isin
        id
      }
      id
    }
    slug
    ... on CompanyReport {
      reportUrl
    }
    ... on ThirdPartyCompanyReport {
      reportUrl
    }
    ... on StockExchangeRelease {
      reportUrl
    }
    ...ContentBasicInfo
    ...ContentMetadata
    ...PriceAndRecommendation_Content
    ...CompanyDetails_Content
    ...ReportLink_Content
    ...KeyFigures_Content
  }
  ...TrendingContent_1jQ2Cn
}

fragment ForumPosts on ForumPost {
  text
  likesCount
  url
  author
  postedAt
  authorImgUrl
}

fragment KeyFigures_Content on Content {
  __isContent: __typename
  companies {
    defaultInstrument {
      estimateData {
        modelType
        reportingCurrency
      }
      snapshot {
        transaction {
          date
          actualized {
            year
            quarter
            revenue
            revenueGrowth
            ebitAdjusted
            ebitReported
            ebitda
            enterpriseValue
            epsAdjusted
            dividend
            dividendYield
            sharePrice
          }
          estimates {
            year
            quarter
            revenue
            revenueGrowth
            ebitAdjusted
            ebitReported
            ebitda
            enterpriseValue
            epsAdjusted
            dividend
            dividendYield
            sharePrice
          }
        }
      }
      id
    }
    id
  }
}

fragment PriceAndRecommendation_Content on Content {
  __isContent: __typename
  createdAt
  companies {
    id
    name
    viewerIsFollowing
    defaultInstrument {
      snapshot {
        priceData {
          date
          lastPrice
          tradeCurrency
        }
        transaction {
          date
          recommendation
          targetPrice
        }
        prevTransaction {
          recommendation
        }
      }
      id
    }
  }
}

fragment PublishingDetails on Content {
  __isContent: __typename
  createdAt
  publishers {
    name
    imgUrl
  }
  authors {
    __typename
    id
    name
    slug
    imgUrl
    jobTitle
  }
  ... on Video {
    liveTime
  }
  ... on Webcast {
    liveTime
  }
}

fragment Reactions on Content {
  __isContent: __typename
  id
  reactionGroups {
    reactionType
    reactionsCount
    viewerReacted
  }
}

fragment ReportLink_Content on Content {
  __isContent: __typename
  type
  isPremium
  ... on CompanyReport {
    reportUrl
  }
  ... on ThirdPartyCompanyReport {
    reportUrl
  }
  ... on StockExchangeRelease {
    reportUrl
  }
}

fragment TrendingContent_1jQ2Cn on Query {
  trendingContent(type: ARTICLE) {
    __typename
    id
    title
    lang
    pageUrl
    createdAt
    type
    imgUrl
    companies {
      squareLogoUrl
      id
    }
    authors {
      __typename
      imgUrl
      id
    }
    publishers {
      imgUrl
    }
  }
}


asarina-pharmas-positive-phase-iia-tourette-syndrome-results-to-be-presented-at-ticcon-the-virtual-national-conference-of-the-tourette-association-of-america

__typename

title

isPremium

lang

htmlBody

companies

createdAt

publishers

authors

reactionGroups

pageUrl

alternatePageUrls

imgUrl

description

Asarina Pharma

(Stockholm, May 5, 2023) On May 19, 2023 Asarina Pharma's positive results from its Phase IIa Study in Tourette Syndrome will be presented at TicCon, the Virtual National Conference of the Tourette...

<div class="abstract"><p>(Stockholm, May 5, 2023) On May 19, 2023 Asarina Pharma's positive results from its Phase IIa Study in Tourette Syndrome will be presented at TicCon, the Virtual National Conference of the Tourette Association of America, by Assoc. Prof. Marco Bortolato (Dept Pharmacology &amp; Toxicology, University of Utah). The results were an important target validation of Assoc Prof. Bortolato's thesis that the powerful neurosteroid Allopregnanolone (ALLO) is a key target in the pathogenesis of Tourette, and that Asarina's endogenous compound Sepranolone modulates ALLO's effects.</p></div>The Phase IIa results demonstrated that Sepranolone could become the first-line pharma treatment for Tourette as it showed competitive tic reduction and improved quality of life while displaying no CNS off-target effects. Sepranolone not only reduced tic severity in its primary clinical endpoint as measured by YGTSS (the world-standard Yale Global Tic Severity Scale) - but also achieved positive results in four key secondary endpoints compared with standard of care:<ul><li>69% greater increase of Quality of Life (using the Gilles de la Tourette Syndrome Quality of Life total score (GTS-QOL)</li><li>50% greater reduction in impairment (YGTSS)</li><li>44% greater reduction of the premonitory urge to tic (PUTS - the Premonitory Urge to Tic scale)</li><li>no off-target CNS effects or systemic side effects - a crucial metric for CNS drugs in an indication where legacy and new treatments in developments involve sometimes severe side effects</li></ul><p>Assoc Prof Bortolato will present at 9.30 PM CET on May 19 in TicCon's Virtual Research Symposium. The presentation is entitled Putative novel pharmacological treatments for tic disorders. Register for the event here: <a href="https://touretteconference.org/en/registration">https://touretteconference.org/en/registration</a></p><p>Asarina Pharma CEO Peter Nordkild: "we are excited that Professor Bortolato will be presenting these important results at such a key event in the Tourette calendar. We believe these results are an exciting step towards Sepranolone ultimately becoming the first-line pharmaceutical treatment for Tourette Syndrome - with no off-target effects and none of the severe side effects associated with today's treatments."&nbsp;</p>

Asarina Pharma's positive Phase IIa Tourette Syndrome results to be presented at TicCon, the Virtual National Conference of the Tourette Association of America

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