Copyright © Inderes 2011 - present. All rights reserved.
Log in to receive notifications.
  • Latest
  • Markets
    • Stock Comparison
    • Financial Calendar
    • Dividends Calendar
    • Research
    • Articles
  • inderesTV
  • Forum
  • About Us
    • Our Coverage
    • Team
Press release

Data supporting the use of Mendus’ DCOne platform to improve production of ovarian cancer TIL therapies presented at ITOC conference

04.04.2025, 08.00
Mendus

Mendus AB ("Mendus" publ; IMMU. ST), a biopharmaceutical company focused on immunotherapies targeting tumor recurrence, today announced that the company has presented data supporting the use of its DCOne platform to expand ovarian cancer tumor-infiltrating lymphocytes (TILs) at the Immunotherapy of Cancer Conference (ITOC). The data support the use of Mendus’ DCOne platform to overcome key hurdles in the production of TIL-based therapies for solid tumor indications.

Adoptive cell therapies based on tumor-infiltrating lymphocytes derived from patients’ tumor tissues have proven successful in melanoma and are also being developed as a promising new treatment for other solid tumors. The production of therapeutic quantities of TILs is dependent on reliable methods to massively expand these cells extracted from available tumor material collected via surgery, while maintaining their functional characteristics needed to fight cancer cells upon reinjection. In collaboration with academic collaborators at the University Medical Center Groningen (UMCG), Mendus has explored the use of its proprietary DCOne platform to expand functional TILs from ovarian cancer tissue samples. The data presented during the ITOC conference on April 3 demonstrate that TIL production can be significantly improved with dendritic cells derived from Mendus’ DCOne cell line. Addition of DCOne mDCs resulted in at least five times higher TIL expansion, with the majority being effector-memory T cells. The DCOne platform can therefore be used to improve the quantity and quality of TILs for treatment of patients with ovarian cancer and other solid tumors.

Mendus’ DCOne platform provides for GMP-grade, off-the-shelf leukemic-derived dendritic cells. Based on the company’s know-how of dendritic cell biology, Mendus has been working on the ex vivo expansion of immune cells as a basis for novel adoptive cell therapies, including memory NK cells associated with improved survival in blood-borne tumors. The data presented at ITOC indicate that the platform is versatile and can also be used for the production of TILs, an upcoming therapy for solid tumors.

Mendus has secured a number of grants to support its research programs and collaborations, including the Oncode Accelerator program and a public-private partnership grant with UMCG from Health~Holland. Mendus has an ongoing clinical collaboration with UMCG for the ALISON study, a Phase I trial evaluating safety and efficacy of Mendus’ lead product vididencel in high-grade serous ovarian cancer patients.

For more information, please contact:
Erik Manting
Chief Executive Officer
E-mail: ir@mendus.com

About Mendus AB (publ)

Mendus is dedicated to changing the course of cancer treatment by addressing tumor recurrence and improving long-term survival for cancer patients, while preserving health and quality of life. We leverage our understanding of dendritic cell biology to develop an advanced clinical pipeline of immunotherapies which combine clinical efficacy with a benign safety profile. Based in Sweden and The Netherlands, Mendus is publicly traded on the Nasdaq Stockholm under the ticker IMMU.ST. https://www.mendus.com/

Attachments
Data supporting the use of Mendus’ DCOne platform to improve production of ovarian cancer TIL therapies presented at ITOC conference

Find us on social media
  • Inderes Forum
  • Youtube
  • Facebook
  • X (Twitter)
Get in touch
  • info@hcandersencapital.dk
  • Bredgade 23B, 2. sal
    1260 København K
Inderes
  • About us
  • Our team
  • Inderes as an investment
  • Services for listed companies
Our platform
  • FAQ
  • Terms of service
  • Privacy policy
  • Disclaimer
Inderes’ Disclaimer can be found here. Detailed information about each share actively monitored by Inderes is available on the company-specific pages on Inderes’ website. © Inderes Oyj. All rights reserved.

  • Latest
  • Markets
    • Stock Comparison
    • Financial Calendar
    • Dividends Calendar
    • Research
    • Articles
  • inderesTV
  • Forum
  • About Us
    • Our Coverage
    • Team

Privacy preferences

Inderes uses cookies to provide a better user experience and a personalised service. By consenting to the use of cookies, we can develop an even better service and will be able to provide content that is interesting to you.